Superbug resistant to all drugs

I am posting an article carried in reuters a few days ago about the emergence of a super bug gene which will confer bacteria with resistance to all known antibiotics.

I can’t help wondering about the nature’s “check and balance’. We have developed such powerful antibiotics, like the carbapenems and yet the bugs can develop resistance to these drugs after a few years.

Humans are actually very insignificant in this universe, read my old ‘Keep life in perspective‘, yet we are still  fighting as to who come first and who come last.. When disasters or  a super-infection strike,  all those who camce first and who came last will be equally affected, and yet we choose to ignore this and fighting for the sake of fighting… Sigh!

Scientists find new superbug spreading from India

(Reuters) – A new superbug from India could spread around the world — in part because of medical tourism — and scientists say there are almost no drugs to treat it.

Researchers said on Wednesday they had found a new gene called New Delhi metallo-beta-lactamase, or NDM-1, in patients in South Asia and in Britain.

U.S. health officials said on Wednesday there had been three cases so far in the United States — all from patients who received recent medical care in India, a country where people often travel in search of affordable healthcare.

NDM-1 makes bacteria highly resistant to almost all antibiotics, including the most powerful class called carbapenems. Experts say there are no new drugs on the horizon to tackle it.

“It’s a specific mechanism. A gene that confers a type of resistance (to antibiotics),” Dr. Alexander Kallen of the U.S. Centers for Disease Control and Prevention in Atlanta said in a telephone interview.

With more people traveling to find less costly medical treatments, particularly for procedures such as cosmetic surgery, Timothy Walsh, who led the study, said he feared the new superbug could soon spread across the globe.

“At a global level, this is a real concern,” Walsh, from Britain’s Cardiff University, said in telephone interview.

“Because of medical tourism and international travel in general, resistance to these types of bacteria has the potential to spread around the world very, very quickly. And there is nothing in the (drug development) pipeline to tackle it.”

Almost as soon as the first antibiotic penicillin was introduced in the 1940s, bacteria began to develop resistance to its effects, prompting researchers to develop many new generations of antibiotics.

But their overuse and misuse have helped fuel the rise of drug-resistant “superbug” infections like methicillin-resistant Staphyloccus aureus, or MRSA.

MEDICAL TOURISM

In a study published in The Lancet Infectious Diseases journal on Wednesday, Walsh’s team found NDM-1 was becoming more common in Bangladesh, India, and Pakistan and was also imported back to Britain in patients returning after treatment.

“India also provides cosmetic surgery for other Europeans and Americans, and it is likely NDM-1 will spread worldwide,” the scientists wrote in the study.

Walsh and his international team collected bacteria samples from hospital patients in two places in India, Chennai and Haryana, and from patients referred to Britain’s national reference laboratory from 2007 to 2009.

They found 44 NDM-1-positive bacteria in Chennai, 26 in Haryana, 37 in Britain, and 73 in other sites in Bangladesh, India and Pakistan. Several of the British NDM-1 positive patients had traveled recently to India or Pakistan for hospital treatment, including cosmetic surgery, they said.

NDM-1-producing bacteria are resistant to many antibiotics including carbapenems, the scientists said, a class of the drugs reserved for emergency use and to treat infections caused by other multi-resistant bugs like MRSA and C-Difficile.

Kallen of the CDC said the United States considered the infection a “very high priority,” but said carbapenem resistance was not new in the United States. “The thing that is new is this particular mechanism,” he said.

Experts cited two drugs that can stand up to carbapenem-resistant infections — colistin, an older antibiotic that has some toxic side effects, and Pfizer’s Tygacil.

For many years, antibiotic research has been a “Cinderella” sector of the pharmaceuticals industry, reflecting a mismatch between the scientific difficulty of finding treatments and the modest sales such products are likely to generate, since new drugs are typically saved only for the sickest patients.

But the increasing threat from superbugs is encouraging a rethink at the few large drugmakers still hunting for new antibiotics, including Pfizer, Merck, AstraZeneca, GlaxoSmithKline and Novartis.

Anders Ekblom, global head of medicines development at AstraZeneca, whose Merrem antibiotic was the leading carbapenem, said he saw “great value” in investing in new antibiotics.

“We’ve long recognized the growing need for new antibiotics, he said. “Bacteria are continually developing resistance to our arsenal of antibiotics and NDM-1 is just the latest example.”

6 Comments (+add yours?)

  1. CYC
    Aug 16, 2010 @ 11:44:23

    Bug first or drug first ? Perhaps the world renowned pharmaceutical companies could shade some lights. Just wonder if there is a conspiracy? Am I weird to think along this direction ?

    Like

  2. iamyuanwu
    Aug 16, 2010 @ 14:00:58

    I remember reading an article some time ago that there are alternatives of using Bacteriophage virus to counter bacterial infection… since bacteriophages can be highly specific. I googled a bit and found that it’s called phage therapy. And apparently still used in Georgia.

    And bacteriophages can mutate/evolve along bacteria and thus negating the super-bug issue. Maybe it’s time we look into this again?

    Imagine, injecting viruses into the body as a cure towards bacterial infection. Errrrggghhh!

    Like

  3. disgusted
    Aug 16, 2010 @ 19:01:36

    It is common knowledge on the truth that all things evolve, from crystals to virus/bacteria and all forms of lives. Nothing is permanent and all things changes.

    The world population reaching some 7 billion is overpopulated and diseases can spread like wildfire with “no borders” sophisticated super jets and transportation. Super invention of germicide warfare and creating new viruses, aided by anti-biotic overdose, comes the superman virus and bacteria.

    With steroids falling from the sky, bringing new “alien” bacterium visitors from outer space.

    Well, the only “living thing” NOT affected are ghosts and spirits. Isn’t it time we wish certain politicians should drop dead with the good intention that they won’t get sick from these super bacteria/viruses.

    Like

  4. Gordy
    Aug 17, 2010 @ 03:15:57

    I don’t think it’s a mere coincidence that the superbug made its debut in India, a country where the use of antibiotics is unregulated. Inappropriate use of antibiotics is bound to increase the level of resistance.

    Like

  5. A true Malaysian
    Aug 17, 2010 @ 10:30:30

    All things happen because of 因果。

    Superbug resistant to all drugs is no exception to 因果。

    Dr. Hsu, maybe you can translate better what is 因果。 Everything in this world is keep changing, evolving and can never be fixed at any point in time. Suffering can never be eliminated by medical sciences. Antibiotics may relief pains (sufferings) but never eliminating them.

    Man, having wisdom and intelligence, have the duties to balance-up the co-existences of all things in this planet. We can never eliminate all bugs, superbug as they have the right to exist in this world as well.

    Understanding of 因果, especially among the scientists will do a lot of good in their contribution to humanity.

    Like

  6. Russ
    Nov 11, 2010 @ 03:52:53

    The best way to prevent MRSA, H1N1 and other SUPERBUGS is to keep all surfaces clean, including skin. Sites to go to are: http://www.antimicrobialsoap.org, http://www.buyveridien.com, and http://www.vansdeals.com. Go to http://www.antimicrobialsoap.org for free report. Contact rdvz@live.com for free freight on all orders.

    Like

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